Dr. Horowitz's research has identified genes that no one knew were involved in brain tumor formation. His discovery of recurrent SMO and AKT1 mutations in meningiomas was published in the Journal of Neurosurgery, and his identification of MYBL1 rearrangements in pediatric low-grade gliomas appeared in the Proceedings of the National Academy of Sciences (PNAS) — findings that are reshaping how these tumors are classified. He earned his PhD in neuroscience from Northwestern, trained in surgery at Brigham and Women's / Boston Children's Hospital, and completed a skull base oncology fellowship at MD Anderson Cancer Center. He's funded by the Department of Defense Neurofibromatosis Research Program and co-leads UChicago's Pituitary and Neuroendocrine Disorders Program.
Education & Training
B.A., Northwestern University
M.D./Ph.D. (Neuroscience), Northwestern Feinberg School of Medicine
Residency, Neurosurgery, Brigham & Women's / Boston Children's
Fellowship, Skull Base Oncology, MD Anderson Cancer Center
Funding & Roles
Dept. of Defense Neurofibromatosis Research Program
Brain Science Foundation
Co-Director, Pituitary & Neuroendocrine Program
Published in Nature Genetics, PNAS, J Neurosurg
Selected Publications
Bi WL, Abedalthagafi M, Horowitz P, et al. Genomic landscape of intracranial meningiomas. J Neurosurg. 2016. PMID: 26771848
Ramkissoon LA, Horowitz PM, et al. Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in MYBL1. PNAS. 2013. PMID: 23633565
Areas of Expertise
Skull Base TumorsPituitary TumorsMeningiomaNeurofibromatosisEndoscopic EndonasalTumor Genetics
